Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study

BMC Research Notes

Thomas Olsen¹  Kathrine J. Vinknes¹  Nasser E. Bastani¹  Helga Refsum¹  Bente Øvrebø²  Cheryl Turner³ 

[1] Department of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway;Department of Nutrition, Institute of Medical Biosciences, Domus Medica, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway;Department of Sport Science and Physical Education, University of Agder, 4604, Kristiansand, Norway;Department of Pharmacology, University of Oxford, OX1 3QT, Oxford, UK;

关键词: Methionine restriction;    Cysteine restriction;    Oral glucose tolerance;    SCD;    Fatty acids;    Pyruvate;   

DOI  :  10.1186/s13104-021-05463-5

来源: Springer

【 摘 要 】

ObjectiveIn this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cyslow + PUFA diet vs. Met/Cyshigh + SFA.ResultsThe diet groups consisted of five women and two men, aged 20–38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cyslow + PUFA group. In the Met/Cyshigh + SFA group, median pre- and post-OGTT glucose concentrations were 4.8 mmol/L and 4.65 mmol/L after the 7-d intervention. The responses in the amino acid profiles were similar in both groups during the intervention with the exception of serine. Fatty acids decreased from baseline to day 7 in both groups. Plasma lactate and pyruvate were similar for both groups with an increase to day 3 before approaching baseline values at day 7.Trial registrationClinicalTrials.gov: NCT02647970, registration date: January 6th 2016.

【 授权许可】

CC BY