Establishing a common metric for patient-reported outcomes in cancer patients: linking patient reported outcomes measurement information system (PROMIS), numerical rating scale, and patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE)

Journal of Patient-Reported Outcomes

Amylou C. Dueck¹  Paul J. Novotny²  Kathleen J. Yost²  Jeff A. Sloan²  Benjamin D. Schalet³  David Cella³  Minji K. Lee⁴ 

[1] Department of Health Sciences Research, Mayo Clinic, 13400 E. Shea Blvd, 85259, Scottsdale, AZ, USA;Department of Health Sciences Research, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA;Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 625 Michigan Ave, 27th Floor, 60611, Chical, IL, USA;Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First St SW, 55906, Rochester, MN, USA;

关键词: Linking;    PROMIS;    PRO-CTCAE;    NRS;   

DOI  :  10.1186/s41687-020-00271-0

来源: Springer

【 摘 要 】

BackgroundResearchers and clinicians studying symptoms experienced by people with cancer must choose from various scales. It would be useful to know how the scores on one measure translate to another.MethodsUsing item response theory (IRT) with the single-group design, in which the same sample answers all measures, we produced crosswalk tables linking five 0–10 numeric rating scale (NRS) and 15 items from Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE, scored on a 1–5 scale) to the T-Score metric of six different scales from the NIH Patient reported Outcomes Measurement Information System (PROMIS®). The constructs, for which we conducted linking, include emotional distress-anxiety, emotional distress-depression, fatigue, sleep disturbance, pain intensity, and pain interference. We tested the IRT linking assumption of construct similarity between measures by comparing item content and testing unidimensionality of item sets comprising each construct. We also investigated the correlation of the measures to be linked and, by inspecting standardized mean differences, whether the linkage is invariant across age and gender subgroups. For measures that satisfied the assumptions, we conducted linking.ResultsIn general, an NRS score of 0 corresponded to about 38.2 on the PROMIS T-Score scale (mean = 50; SD = 10); whereas an NRS score of 10 corresponded to a PROMIS T-Score of approximately 72.7. Similarly, the lowest/best score of 1 on PRO-CTCAE corresponded to 39.8 on T-score scale and the highest/worst score of 5 corresponded to 72.0.ConclusionWe produced robust linking between single item symptom measures and PROMIS short forms.

【 授权许可】

CC BY