Anemia predicts poor outcomes of COVID-19 in hospitalized patients: a prospective study in Iran

BMC Infectious Diseases

Mahdieh Abbasalizad Farhangi¹  Mohammad Hossein Somi²  Masood Faghih Dinevari²  Zeinab Nikniaz²  Elham Sadeghi Majd³ 

[1] Community Nutrition Department, Tabriz University of Medical Sciences, Tabriz, Iran;Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: COVID-19;    Anemia;    Mortality;    Ventilator requirement;    ICU admission;   

DOI  :  10.1186/s12879-021-05868-4

来源: Springer

【 摘 要 】

BackgroundThere are limited number of studies with controversial findings regarding the association between anemia at admission and coronavirus disease 2019 (COVID-19) outcomes. Therefore, in this research, we aimed to investigate the prospective association between anemia and COVID-19 outcomes in hospitalized patients in Iran.MethodsIn this prospective study, the data of 1274 consecutive patients hospitalized due to COVID-19 were statistically analyzed. All biomarkers, including hemoglobin and high-sensitivity C-reactive protein (hs-CRP) levels were measured using standard methods. Anemia was defined as a hemoglobin (Hb) concentration of less than 13 g/dL and 12 g/dL in males and females, respectively. Assessing the association between anemia and COVID-19 survival in hospitalized patients was our primary endpoint.ResultsThe mean age of the participants was 64.43 ± 17.16 years, out of whom 615 (48.27%) were anemic subjects. Patients with anemia were significantly older (P = 0.02) and had a higher frequency of cardiovascular diseases, hypertension, kidney disease, diabetes, and cancer (P < 0.05). The frequency of death (anemic: 23.9% vs. nonanemic: 13.8%), ICU admission (anemic: 27.8% vs. nonanemic:14.71%), and ventilator requirement (anemic: 35.93% vs. nonanemic: 20.63%) were significantly higher in anemic patients than in nonanemic patients (P < 0.001). According to the results of regression analysis, after adjusting for significant covariate in the univariable model, anemia was independently associated with mortality (OR: 1.68, 95% CI: 1.10, 2.57, P = 0.01), ventilator requirement (OR: 1.74, 95% CI: 1.19, 2.54, P = 0.004), and the risk of ICU admission (OR: 2.06, 95% CI: 1.46, 2.90, P < 0.001).ConclusionThe prevalence of anemia in hospitalized patients with COVID-19 was high and was associated with poor outcomes of COVID-19.

【 授权许可】

CC BY