The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients

BMC Infectious Diseases

Rossana Colla¹  Laura Albertazzi¹  Simone Canovi¹  Tommaso Fasano¹  Efrem Bonelli²  Paolo Giorgi Rossi³  Marta Ottone³  Alessandro Zerbini⁴  Valentina Iotti⁵  Pierpaolo Pattacini⁵  Giulia Besutti⁶ 

[1] Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy;Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy;Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy;Epidemiology Unit, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy;Laboratory of autoimmunity, allergology and innovative biotechnologies, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy;Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy;Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy;Clinical and Experimental Medicine PhD program, University of Modena and Reggio Emilia, Modena, Italy;

关键词: COVID-19;    Clinical laboratory;    Computed tomography;   

DOI  :  10.1186/s12879-021-05855-9

来源: Springer

【 摘 要 】

BackgroundLaboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients.MethodsThis was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2.ResultsIncluded were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation.ConclusionsPulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.

【 授权许可】

CC BY