Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders

BMC Pulmonary Medicine

Pietro Pirina¹  Leonardo Antonicelli²  Angelo Guido Corsico³  Roberto Bono⁴  Francesca Locatelli⁵  Eliana Finocchio⁵  Francesca Sanna⁵  Pierpaolo Marchetti⁵  Giuseppe Verlato⁵  Roberta Vesentini⁵  Nicola Murgia⁶  Gianluca Spiteri⁷  Mario Olivieri⁷  Marcello Ferrari⁸  Salvatore Battaglia⁹ 

[1] Department of Clinical, Surgical and Experimental Sciences, University of Sassari, Piazza Università, 21, 07100, Sassari, Italy;Department of Internal Medicine Ospedali Riuniti Ancona, Via Conca, 71, 60126, Ancona, Italy;Department of Internal Medicine and Medical Therapy, University of Pavia, Palazzo Botta, 10, 27100, Pavia, Italy;Department of Public Health and Pediatrics, University of Torino, Via Santena 5 bis, 10126, Torino, Italy;Section of Epidemiology and Medical Statistics, Department of Diagnostic and Public Health, University of Verona, Strada Le Grazie, 8, 37134, Verona, Italy;Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Piazza dell’Università, 1, 06123, Perugia, Italy;Unit of Occupational Medicine, Department of Diagnostics and Public Health, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy;Unit of Respiratory Diseases, Department of Medicine, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy;University of Palermo, Piazza Marina, 61, 90133, Palermo, Italy;

关键词: Gastritits;    Gastroesophageal reflux disease;    Allergic rhinitis;    Non-allergic rhinitis;    Sinusitis;   

DOI  :  10.1186/s12890-020-01364-8

来源: Springer

【 摘 要 】

BackgroundGastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.AimsTo evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis.MethodsWe investigated 2887 subjects aged 20–84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Subjects were asked if they had doctor-diagnosed “gastritis or stomach ulcer (confirmed by gastroscopy)” or “gastroesophageal reflux disease, hiatal hernia or esophagitis”. The association between NAR/AR/sinusitis and either gastritis or GERD was evaluated through relative risk ratios (RRR) by multinomial logistic regression.ResultsThe prevalence of gastritis/GERD increased from subjects without nasal disturbances (22.8% = 323/1414) to subjects with AR (25.8% = 152/590) and further to subjects with NAR (36.7% = 69/188) or sinusitis (39.9% = 276/691). When adjusting for centre, sex, age, education level, BMI, smoking habits and alcohol intake, the combination of gastritis and GERD was associated with a four-fold increase in the risk of NAR (RRR = 3.80, 95% CI 2.56–5.62) and sinusitis (RRR = 3.70, 2.62–5.23) with respect to controls, and with a much smaller increase in the risk of AR (RRR = 1.79, 1.37–2.35)..ConclusionThe study confirmed the association between gastritis/GERD and nasal disturbances, which is stronger for NAR and sinusitis than for AR.

【 授权许可】

CC BY