Oxycodone versus other opioid analgesics after laparoscopic surgery: a meta-analysis

European Journal of Medical Research

Jun Ma¹  Yan Li²  Qi Wang³  Jiaxiang Ni³  Zhi Dou³  Liqiang Yang³ 

[1] Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, 100029, Beijing, China;Department of Anesthesiology, The People’s Hospital of Jizhou District, 301900, Tianjin, Tianjin, China;Center for Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, 100029, Beijing, China;Department of Pain Management, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China;Department of Pain Management, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China;

关键词: Meta-analysis;    Oxycodone;    Laparoscopic surgery;    Postoperative visceral pain;   

DOI  :  10.1186/s40001-020-00463-w

来源: Springer

【 摘 要 】

BackgroundIntravenous opioids are administered for the management of visceral pain after laparoscopic surgery. Whether oxycodone has advantages over other opioids in the treatment of visceral pain is not yet clear.MethodsIn this study, the analgesic efficiency and adverse events of oxycodone and other opioids, including alfentanil, sufentanil, fentanyl, and morphine, in treating post-laparoscopic surgery visceral pain were evaluated. This review was conducted according to the methodological standards described in the Cochrane Handbook for Systematic Reviews of Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. The PubMed, Embase, and Cochrane databases were searched in December 2019.ResultsTen studies were included in this review. The sample size was 695 participants. The results showed that compared with morphine and fentanyl, oxycodone had a more potent analgesic efficacy on the first day after laparoscopic surgery, especially during the first 0.5 h. There was no significant difference in sedation between the two groups. Compared to morphine and fentanyl, oxycodone was more likely to lead to dizziness and drowsiness. Overall, patient satisfaction did not differ significantly between oxycodone and other opioids.ConclusionsOxycodone is superior to other analgesics within 24 h after laparoscopic surgery, but its adverse effects should be carefully considered.

【 授权许可】

CC BY