Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke

BMC Neurology

Hong-Qi Li¹  Jin-Tai Yu¹  Xiao-Ling Zhong²  Jian-Jun Yin³  Fu-Rong Sun⁴  Ya-Hui Ma⁴  Lan Tan⁴  Liang-Yu Huang⁴  Jing-Hui Song⁵ 

[1] Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, 12th Wulumuqi Zhong Road, 200040, Shanghai, China;Department of Neurology, Qingdao Central Hospital, Qingdao University, Qingdao, China;Department of Neurology, Qingdao Hiser Hospital, Qingdao University, Qingdao, China;Department of Neurology, Qingdao Municipal Hospital, Qingdao University, 266071, Qingdao, China;Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China;

关键词: Intracranial artery stenosis;    Ischemic stroke;    Neutrophil to lymphocyte ratio;    Mediation analysis;   

DOI  :  10.1186/s12883-021-02073-3

来源: Springer

【 摘 要 】

BackgroundThe neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to examine the associations of NLR with ICAS and ischemic stroke among a large and high-risk population.MethodsParticipants with records of clinical characteristics were prospectively recruited from the Neurology Department and Health & Physical Examination Center of Qingdao Municipal Hospital. Logistic regression analysis was used to examine the associations of NLR with ICAS and ischemic stroke. Moreover, we also conducted parametric mediation analysis to estimate the effect of NLR on the risk of ischemic stroke mediated through ICAS.ResultsA total of 2989 participants were enrolled in this study. After adjusting for covariates, NLR (OR = 1.125, 95%CI 1.070–1.183) and ICAS (OR = 1.638, 95%CI 1.364–1.967) were significantly associated with ischemic stroke. Compared with the first quartile NLR, the second, third and fourth quartiles NLR were independent risk predictors for ischemic stroke (P for trend < 0.001); the third and fourth quartiles were independent predictors for ICAS (P for trend < 0.001). The mediation analysis showed that ICAS partially mediated the association between NLR and ischemic stroke, accounting for 14.4% of the total effect (P < 0.001).ConclusionsNLR was significantly associated with ICAS and ischemic stroke. Besides, ICAS partially mediated the association between NLR and ischemic stroke.

【 授权许可】

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