Foot‐and‐mouth disease virus infection in the domestic dog (Canis lupus familiaris), Iran

BMC Veterinary Research

Keith Sumption¹  Darab Abdollahi²  Reza Hassanzadeh²  Jemma Wadsworth³  Ryan A. Waters³  Nick J. Knowles³  Valerie Mioulet³  Andrew E. Shaw³  Donald P. King³ 

[1] Food and Agriculture Organization for the United Nations (FAO), Rome, Italy;Iran Veterinary Organisation (IVO), Vali Asr Avenue, Tehran, Iran;The Pirbright Institute, Ash Road, GU24 0NF, Woking, Surrey, UK;

关键词: Foot-and-Mouth Disease;    Virus;    FMD;    FMDV;    Heart;    Cardiac;    Dog;    Myocardium;    Iran;   

DOI  :  10.1186/s12917-021-02769-1

来源: Springer

【 摘 要 】

BackgroundFoot-and-mouth disease (FMD) is a highly infectious viral disease, recognised to affect animals in the order Artiodactyla. The disease is rarely fatal in adult animals, however high mortality is associated with neonatal and juvenile infection.Case presentationFive puppies died after being fed lamb carcases, the lambs having died during an outbreak of FMD in Iran. Following a post-mortem examination, cardiac tissue from one of the dead puppies was subjected to virus isolation, antigen ELISA, real-time RT-PCR, sequencing and confocal microscopy to assess the presence and characteristics of any FMD virus. The virological and microscopic examination of the cardiac tissue provided evidence of FMD virus replication in the canine heart.ConclusionsThe data generated in this study demonstrate for the first time that FMD virus can internalise and replicate in dogs and may represent an epidemiologically significant event in FMD transmission, highlighting the dangers of feeding diseased animal carcases to other species. The reporting of this finding may also focus attention on similar disease presentations in dogs in FMD endemic countries allowing a better understanding of the prevalence of such events.

【 授权许可】

CC BY