Insights of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) pandemic: a current review

Biological Procedures Online

Santosh Kumar Karn¹  Gaurav Verma²  Prashant Katiyar³  Nitin Baliyan³  Ankit Kumar Chauhan⁴  Jyoti Choudhary⁵  Shrivardhan Dheeman⁶  Manoj Kumar Sarangi⁷  Vipin Sharma⁸ 

[1] Deaprtment of Biotechnology and Biochemistry, School of Life Sciences, Sardar Bhagwan Singh University, 248161, Dehradun, Uttarakhand, India;Deaprtment of Microbiology, Shri Dev Suman Subharti Medical College, Ras Bihari Bose Subharti University, 248001, Dehradun, Uttarakhand, India;Department of Botany and Microbiology, Gurukula Kangri Deemed to be University, 249404, Haridwar, Uttarakhand, India;Department of Botany and Microbiology, Gurukula Kangri Deemed to be University, 249404, Haridwar, Uttarakhand, India;Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, 110001, New Delhi, India;Department of Microbiology, Chinmaya Degree College (Hemwati Nandan Bahuguna Garhwal University, Srinagar, Garhwal, Uttarakhand), 249401, Haridwar, Uttarakhand, India;Department of Botany and Microbiology, Gurukula Kangri Deemed to be University, 249404, Haridwar, Uttarakhand, India;Department of Microbiology, School of Life Sciences, Sardar Bhagwan Singh University, 248161, Dehradun, Uttarakhand, India;Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, 248161, Dehradun, Uttarakhand, India;Department of Pharmaceuticals Sciences, Faculty of Ayurvedic and Medicinal Sciences, Gurukula Kangri Deemed to be University, 249404, Haridwar, Uttarakhand, India;

关键词: COVID-19;    Coronavirus;    ACE-2 receptor;    Drug repurposing;   

DOI  :  10.1186/s12575-020-00141-5

来源: Springer

【 摘 要 】

COVID-19, a pandemic of the 21st century caused by novel coronavirus SARS-CoV-2 was originated from China and shallowed world economy and human resource. The medical cures via herbal treatments, antiviral drugs, and vaccines still in progress, and studying rigorously. SARS-CoV-2 is more virulent than its ancestors due to evolution in the spike protein(s), mediates viral attachment to the host’s membranes. The SARS-CoV-2 receptor-binding spike domain associates itself with human angiotensin-converting enzyme 2 (ACE-2) receptors. It causes respiratory ailments with irregularities in the hepatic, nervous, and gastrointestinal systems, as reported in humans suffering from COVID-19 and reviewed in the present article. There are several approaches, have been put forward by many countries under the world health organization (WHO) recommendations and some trial drugs were introduced for possible treatment of COVID-19, such as Lopinavir or Ritonavir, Arbidol, Chloroquine (CQ), Hydroxychloroquine (HCQ) and most important Remdesivir including other like Tocilizumab, Oritavancin, Chlorpromazine, Azithromycin, Baricitinib, etc. RT-PCR is the only and early detection test available besides the rapid test kit (serodiagnosis) used by a few countries due to unreasonable causes. Development of vaccine by several leader of pharmaceutical groups still under trial or waiting for approval for mass inoculation. Management strategies have been evolved by the recommendations of WHO, specifically important to control COVID-19 situations, in the pandemic era. This review will provide a comprehensive collection of studies to support future research and enhancement in our wisdom to combat COVID-19 pandemic and to serve humanity.

【 授权许可】

CC BY