Serum amyloid A1 mediates myotube atrophy via Toll‐like receptors

Journal of Cachexia, Sarcopenia and Muscle

Mihail Todiras¹  Steffen Weber‐Carstens²  Christian Butter³  Ilka Jorde⁴  Katrin Schmoeckel⁴  Barbara M. Bröker⁴  Stephan B. Felix⁵  Melanie Kny⁶  Alexander Hahn⁶  Cristina Pablo‐Tortola⁶  Sibylle Schmidt⁶  Friedrich C. Luft⁶  Jens Fielitz⁷  Marcel Nowak⁸  Ernst Jarosch⁹  Thomas Sommer^1,10  Claus Scheidereit^1,11  Michael Willenbrock^1,11 

[1] Cardiovascular hormones, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Nicolae Testemiţanu State University of Medicine and Pharmacy, Chișinău, Moldova;Department of Anesthesiology and Intensive Care Medicine, Campus Virchow‐Klinikum and Campus Charité Mitte, Charité‐Universitätsmedizin Berlin, Berlin, Germany;Berlin Institute of Health (BIH), Berlin, Germany;Department of Cardiology, Heart Center Brandenburg and Medical University Brandenburg (MHB), Bernau, Germany;Department of Immunology, Institute of Immunology and Transfusion Medicine, University Medicine, Greifswald, Germany;Department of Internal Medicine B, Cardiology, University Medicine Greifswald, Greifswald, Germany;DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany;Experimental and Clinical Research Center, Charité‐Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Experimental and Clinical Research Center, Charité‐Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Department of Internal Medicine B, Cardiology, University Medicine Greifswald, Greifswald, Germany;DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany;Berlin Institute of Health (BIH), Berlin, Germany;Experimental and Clinical Research Center, Charité‐Universitätsmedizin Berlin, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Intracellular Proteolysis, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Intracellular Proteolysis, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Intracellular Proteolysis, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;Institute of Biology, Humboldt‐University Berlin, Berlin, Germany;DZHK (German Center for Cardiovascular Research), Partner Site Berlin, Berlin, Germany;Signal Transduction in Tumor Cells, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;

关键词: Sepsis;    NF‐κB;    CLP;    Muscle atrophy;    ICUAW;   

DOI  :  10.1002/jcsm.12491

来源: Wiley

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CC BY