Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids

Advanced Science

Xuan Wu¹  Cheng‐Jun Sui²  Rui Wu²  Shan Wang³  Xiao‐Fang Zhao³  Ya‐Ni Zhang⁴  Si‐Yun Shen⁵  Yan‐Jing Zhu⁵  Jing Fu⁵  Zhi‐Xuan Li⁵  Lei Chen⁶  Hong‐Yang Wang⁶  Kai‐Ting Wang⁷  Yan Zhao⁷  Jian‐Min Wu⁷  Dong Gao⁸ 

[1] Department of Laboratory Medicine, The Tenth People's Hospital of Shanghai, Tongji University, Shanghai, 200072, China;Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China;Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China;Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, 200438, China;National Center for Liver Cancer, Shanghai, 200441, China;The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China;National Center for Liver Cancer, Shanghai, 200441, China;The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, China;Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China;School of Life Sciences and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, 200438, China;The State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China;Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China;

关键词: drug resistance;    hepatobiliary tumor organoid;    single‐cell analysis;    tumor ecosystem;    tumor heterogeneity;   

DOI  :  10.1002/advs.202003897

来源: Wiley

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