Targeted RNA N6‐Methyladenosine Demethylation Controls Cell Fate Transition in Human Pluripotent Stem Cells

Advanced Science

Yu‐Li Zhao¹  Guo‐Shi Chai¹  Guan‐Zheng Luo¹  Weisheng Cheng²  Zhiju Zhao³  Qingquan Zhao³  Jia Wang³  Xuena Chen³  Nan Cao³ 

[1] MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat‐sen University, Guangzhou, 510275, P.R. China;The Seventh Affiliated Hospital, Zhongshan School of Medicine, Sun Yat‐sen University, Guangdong, 510080, P.R. China;The Seventh Affiliated Hospital, Zhongshan School of Medicine, Sun Yat‐sen University, Guangdong, 510080, P.R. China;Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat‐sen University), Ministry of Education, Guangdong, 510080, P.R. China;

关键词: ALKBH5;    CRISPR;    differentiation;    mA RNA modification;    pluripotent stem cells;   

DOI  :  10.1002/advs.202003902

来源: Wiley

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