Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor

Advanced Science

Changguo Gong¹  Min Shi¹  Yugang Wang¹  Xiao Zhang²  Shuang Wang²  Feng Li³  Wei Wei³  Yan Wang³  Guanghui Ma³ 

[1] Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai, 200336, P. R. China;State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei‐Er‐Tiao, Zhong‐Guan‐Cun, Haidian District, Beijing, 100190, P. R. China;State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, No. 1 Bei‐Er‐Tiao, Zhong‐Guan‐Cun, Haidian District, Beijing, 100190, P. R. China;School of Chemical Engineering, University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, P. R. China;

关键词: combination therapy;    lipids rearrangement;    low pH reprogramming;    patient‐derived xenografts;    tumor exosomes;   

DOI  :  10.1002/advs.202002787

来源: Wiley

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