Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming

Aging Cell

Jun‐Yi Liu¹  Chun‐Feng Liu²  Yu‐Ting Zhang²  Chao Gu³  Shi‐Zhuang Wei⁴  Fen Wang⁴  Hong‐Yang Sun⁵  Guang‐Hui Wang⁵ 

[1] Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China;Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China;Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China;Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China;Department of Pharmacy, Children’s Hospital of Soochow University, Suzhou, China;Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, China;Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuropsychiatric Disorders &, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China;

关键词: DA neurons;    microglia;    MT1;    neuroinflammation;    Parkinson’s disease;    PDHA1;   

DOI  :  10.1111/acel.13375

来源: Wiley

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