CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

EMBO Molecular Medicine

Patrizia Castellani¹  Anna Rubartelli¹  Chiara Passera²  Massimo P Crippa²  Francesca Brambilla²  Francesco De Marchis²  Riccardo Ertassi²  Federica Colombo³  Rosanna Mezzapelle⁴  Samuel Zambrano⁴  Marco E Bianchi⁴  Renzo Boldorini⁵  Francesca Sanvito⁶  Manuela Leo⁷  Lina Sabatino⁷  Vittorio Colantuoni⁷  Angelo Carretta⁸  Veronica Basso⁹  Anna Mondino⁹  Maura Casalgrandi^1,10  Alessandro Preti^1,10  Francesca Caprioglio^1,11  Marco Silingardi^1,11  Ottavio Rena^1,12 

[1] Cell Biology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy;Chromatin Dynamics Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy;Chromatin Dynamics Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy;Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, Italy;Chromatin Dynamics Unit, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy;School of Medicine, Vita‐Salute San Raffaele University, Milan, Italy;Department of Health Science, School of Medicine, University of Eastern Piedmont Amedeo Avogadro, Vercelli, Italy;Pathology Unit, Maggiore della Carità Hospital, Novara, Italy;Department of Pathology, IRCCS San Raffaele Scientific Institute, Milan, Italy;Department of Sciences and Technologies, University of Sannio, Benevento, Italy;Department of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy;Division of Immunology, Transplantation and Infectious Diseases, Lymphocyte Activation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;HMGBiotech S.r.l., Milan, Italy;School of Medicine, Vita‐Salute San Raffaele University, Milan, Italy;Unit of Thoracic Surgery, Maggiore della Carità Hospital, Novara, Italy;

关键词: CD47;    CXCR4;    HMGB1;    immunogenic cell death;    mesothelioma;   

DOI  :  10.15252/emmm.202012344

来源: Wiley

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