l‐tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK‐TRAF6 interactions and inhibiting NF‐κB and MAPK pathways

Journal of Cellular and Molecular Medicine

Hongyuan Song¹  Yajun Wang²  Jin Cui²  Hao Jiang²  Liehu Cao²  Weizong Weng²  Qirong Zhou²  Chao Fang²  Huiwen Chen²  Yan Hu²  Yao Wang²  Xin Zhi³  Xiaoqun Li³  Jiacan Su⁴  Xiao Chen⁵  Sicheng Wang⁶  Lipeng Wang⁷  Longjuan Qin⁸ 

[1] Department of Ophthalmology, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Basic Medical School, Naval Military Medical University, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;China‐South Korea Bioengineering Center, Shanghai, China;Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Department of Chemistry, Fudan University, Shanghai, China;Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai, China;Graduate Management Unit, Shanghai Changhai Hospital, Naval Military Medical University, Shanghai, China;Orthopedic Basic and Translational Research Center, Jiangyin, China;

关键词: ‐tetrahydropalmatine;    osteoclastogenesis;    osteoporosis;    RANKL;   

DOI  :  10.1111/jcmm.14790

来源: Wiley

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