Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker

Journal of Cellular and Molecular Medicine

Sehoon Park¹  Yon Su Kim²  Yaerim Kim³  Soojin Lee⁴  Semin Cho⁴  Jong Joo Moon⁴  Hajeong Lee⁵  Cheol Kwak⁶  Chang Wook Jeong⁶  Jueun Lee⁷  Geum‐Sook Hwang⁸  Joo Young Kim⁹  Kyu Hong Kim⁹  Seung Hee Yang⁹  Minkyoung Park⁹  Jung Pyo Lee^1,10  Chun Soo Lim^1,11  Dong Ki Kim^1,12  Kwon Wook Joo^1,12 

[1] Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea;Department of Internal Medicine, Armed Forces Capital Hospital, Gyeonggi‐do, Korea;Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea;Kidney Research Institute, Seoul National University, Seoul, Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;Department of Urology, Seoul National University Hospital, Seoul, Korea;Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul, Korea;Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul, Korea;Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea;Kidney Research Institute, Seoul National University, Seoul, Korea;Kidney Research Institute, Seoul National University, Seoul, Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea;Kidney Research Institute, Seoul National University, Seoul, Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea;Kidney Research Institute, Seoul National University, Seoul, Korea;Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea;Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;

关键词: glomerulonephritis;    glycine;    IgA nephropathy;    metabolomics;    prognosis;   

DOI  :  10.1111/jcmm.16520

来源: Wiley

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