Comprehensive metabolomic profiling in early IgA nephropathy patients reveals urine glycine as a prognostic biomarker

Journal of Cellular and Molecular Medicine

Sehoon Park¹  Yon Su Kim²  Yaerim Kim³  Soojin Lee⁴  Semin Cho⁴  Jong Joo Moon⁴  Hajeong Lee⁵  Cheol Kwak⁶  Chang Wook Jeong⁶  Jueun Lee⁷  Geum‐Sook Hwang⁸  Joo Young Kim⁹  Kyu Hong Kim⁹  Seung Hee Yang⁹  Minkyoung Park⁹  Jung Pyo Lee^1,10  Chun Soo Lim^1,11  Dong Ki Kim^1,12  Kwon Wook Joo^1,12 

[1]Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

[2]Department of Internal Medicine, Armed Forces Capital Hospital, Gyeonggi‐do, Korea

[3]Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

[4]Kidney Research Institute, Seoul National University, Seoul, Korea

[5]Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

[6]Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

[7]Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea

[8]Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

[9]Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

[10]Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

[11]Department of Urology, Seoul National University Hospital, Seoul, Korea

[12]Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul, Korea

[13]Integrated Metabolomics Research Group, Western Seoul Center, Korea Basic Science Institute, Seoul, Korea

[14]Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea

[15]Kidney Research Institute, Seoul National University, Seoul, Korea

[16]Kidney Research Institute, Seoul National University, Seoul, Korea

[17]Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

[18]Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

[19]Kidney Research Institute, Seoul National University, Seoul, Korea

[20]Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

[21]Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

[22]Kidney Research Institute, Seoul National University, Seoul, Korea

[23]Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

[24]Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

关键词: glomerulonephritis;    glycine;    IgA nephropathy;    metabolomics;    prognosis;   

DOI  :  10.1111/jcmm.16520

来源: Wiley

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