Uraemic extracellular vesicles augment osteogenic transdifferentiation of vascular smooth muscle cells via enhanced AKT signalling and PiT‐1 expression

Journal of Cellular and Molecular Medicine

Antje Ludwig¹  Uwe Querfeld²  Christian Freise³  Matthias Taupitz³  Jörg Schnorr³  Bernd Hamm³ 

[1]Department of Cardiology and Angiology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt‐Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

[2]Department of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt‐Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

[3]Department of Radiology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt‐Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

关键词: chronic kidney disease;    exosomes;    extracellular vesicles;    uraemia;    vascular calcification;    vascular smooth muscle cells;   

DOI  :  10.1111/jcmm.16572

来源: Wiley

【 授权许可】

CC BY