Dual regulation of microglia and neurons by Astragaloside IV‐mediated mTORC1 suppression promotes functional recovery after acute spinal cord injury

Journal of Cellular and Molecular Medicine

Ximiao Chen¹  Zhenxuan Shao²  Yifei Zhou²  Chongan Huang²  Yaosen Wu²  Xuanqi Zheng²  Xiangxiang Pan²  Weiyang Gao²  Jialiang Lin²  Mingbao Gu²  Ben Wang²  Naifeng Tian²  Sunli Hu²  Xiangyang Wang²  Xiaolei Zhang³  Yan Wu⁴  Hao Lin⁵ 

[1] Department of Orthopaedics, Affiliated Hospital of Guilin Medical College, Guilin, Guangxi Province, China;Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China;Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, Zhejiang Province, China;The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China;Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China;Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, Zhejiang Province, China;The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China;Chinese Orthopaedic Regenerative Medicine Society, Hangzhou, Zhejiang Province, China;Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China;The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang Province, China;

关键词: Astragaloside IV;    autophagy;    microglia polarization;    mTORC1;    spinal cord injury;   

DOI  :  10.1111/jcmm.14776

来源: Wiley

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