Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age‐related neurodegeneration

Aging Cell

Brian D. McCabe¹  Emma I. O'Leary²  Elizabeth G. Neureiter³  Silas A. Buck³  Claire E. J. Cheetham⁴  Briana R. De Miranda⁵  J. Timothy Greenamyre⁶  Thomas Steinkellner⁷  Thomas S. Hnasko⁸  Michael J. Palladino⁹  Keri J. Fogle⁹  Ryan W. Logan^1,10  Victoria C. Childers^1,11  Kenneth N. Fish^1,11  Sai H. Bhatte^1,11  Michael Villeneuve^1,11  David A. Lewis^1,11  Despoina Aslanoglou^1,11  Sophie A. Rubin^1,11  Jill R. Glausier^1,11  Zachary Freyberg^1,12 

[1] Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland;Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA;Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA;Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA;Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA;Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA;Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA;Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA;Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA;Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA;Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria;Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA;Research Service, VA San Diego Healthcare System, San Diego, CA, USA;Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA;Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA, USA;Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA;Center for Systems Neurogenetics of Addiction, The Jackson Laboratory, Bar Harbor, ME, USA;Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA;Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA;Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA;

关键词: aging;    dopamine;    Drosophila;    neurodegeneration;    vesicular glutamate transporter;   

DOI  :  10.1111/acel.13365

来源: Wiley

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