Acceleration of ageing via disturbing mTOR‐regulated proteostasis by a new ageing‐associated gene PC4

Aging Cell

Zeyu Yang¹  Qiang Gong²  Min Luo³  Fengying Liao³  Zhongyong Jiang³  Chunmeng Shi³  Chi Zhang³  Qing Wang³  Le Ma³  Long Chen³  Yang Wang³  Peng Luo³  Jie Wu³  Ziwen Wang⁴  Shiqian Han⁵ 

[1] Breast and Thyroid Surgical Department, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China;Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing, China;Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China;Institute of Rocket Force Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, Chongqing, China;Department of Cardiology, Geriatric Cardiovascular Disease Research and Treatment Center, 252 Hospital of PLA (82nd Group Army Hospital of PLA), Baoding, China;Institute of Tropical Medicine, Third Military Medical University, Chongqing, China;

关键词: ageing;    mTOR;    PC4;    protein synthesis;    proteostasis;   

DOI  :  10.1111/acel.13370

来源: Wiley

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