“Protein aggregates” contain RNA and DNA, entrapped by misfolded proteins but largely rescued by slowing translational elongation

Aging Cell

Akshatha Ganne¹  Jay Johnson¹  Srinivas Ayyadevara²  Robert J. Shmookler Reis³  Meenakshisundaram Balasubramaniam⁴  Ramani Atluri⁴ 

[1] BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, USA;Central Arkansas Veterans Healthcare System, Little Rock, AR, USA;Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA;Central Arkansas Veterans Healthcare System, Little Rock, AR, USA;Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA;BioInformatics Program, University of Arkansas for Medical Sciences and University of Arkansas at Little Rock, Little Rock, AR, USA;Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA;

关键词: aggregation;    Alzheimer’s disease;    apolipoprotein E;    beta amyloid;    cotranslational misfolding;    DNA;    endogenous viruses;    functional annotation;    gene ontology;    neurodegeneration;    nucleic acid sequence;    nucleic acids;    protein aggregates;    proteomics;    retrotransposons;    RNA;   

DOI  :  10.1111/acel.13326

来源: Wiley

【 授权许可】

CC BY