Antisense oligonucleotide‐mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet‐induced obesity in mice

Physiological Reports

Thomas Auen¹  Traci A. Czyzyk²  Beth L. Worley³  Amy C. Arnold⁴  Nadine Hempel⁵  Brett P. Monia⁶ 

[1] Department of Anesthesiology & Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, USA;Department of Anesthesiology & Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, USA;Department of Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA;Department of Anesthesiology & Perioperative Medicine, Penn State University College of Medicine, Hershey, PA, USA;Department of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA;Biomedical Sciences Program, Penn State University College of Medicine, Hershey, PA, USA;Department of Neural & Behavioral Sciences, Penn State University College of Medicine, Hershey, PA, USA;Department of Pharmacology, Penn State University College of Medicine, Hershey, PA, USA;Ionis Pharmaceuticals Inc., Carlsbad, CA, USA;

关键词: beta‐oxidation;    cholesterol;    diet‐induced obesity;    ferredoxin reductase;    insulin resistance;    non‐alcoholic fatty liver disease;   

DOI  :  10.14814/phy2.14853

来源: Wiley

【 授权许可】

CC BY