An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

eLife

Mark Clements¹  Jingcheng Zhao²  Gustaf Edgren³  Martin L Olsson⁴  Torsten Dahlén⁵ 

[1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden;Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden;Cardiology Department, Södersjukhuset, Stockholm, Sweden;Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University & Department of Clinical Immunology and Transfusion Medicine, Office of Medical Services, Region Skåne, Lund, Sweden;Hematology Department, Karolinska University Hospital, Stockholm, Sweden;Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden;

关键词: ABO blood group;    RhD blood group;    agnostic;    all disease;    None;   

DOI  :  10.7554/eLife.65658

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Background:There are multiple known associations between the ABO and RhD blood groups and disease. No systematic population-based studies elucidating associations between a large number of disease categories and blood group have been conducted.Methods:Using SCANDAT3-S, a comprehensive nationwide blood donation-transfusion database, we modeled outcomes for 1217 disease categories including 70 million person-years of follow-up, accruing from 5.1 million individuals.Results:We discovered 49 and 1 associations between a disease and ABO and RhD blood groups, respectively, after adjustment for multiple testing. We identified new associations such as a decreased risk of kidney stones and blood group B as compared to blood group O. We also expanded previous knowledge on other associations such as pregnancy-induced hypertension and blood groups A and AB as compared to blood group O and RhD positive as compared to negative.Conclusions:Our findings generate strong further support for previously known associations, but also indicate new interesting relations.Funding:Swedish Research Council.

【 授权许可】

CC BY