Instantaneous movement-unrelated midbrain activity modifies ongoing eye movements

eLife

Xiaoguang Tian¹  Ziad M Hafed¹  Fatemeh Khademi¹  Antimo Buonocore¹ 

[1] Werner Reichardt Centre for Integrative Neuroscience, Tübingen University, Tübingen, Germany;Hertie Institute for Clinical Brain Research, Tübingen University, Tübingen, Germany;

关键词: superior colliculus;    sensory-motor integration;    saccade kinematics;    lateral interaction;    saccadic inhibition;    Rhesus macaque;   

DOI  :  10.7554/eLife.64150

来源: eLife Sciences Publications, Ltd

【 摘 要 】

At any moment in time, new information is sampled from the environment and interacts with ongoing brain state. Often, such interaction takes place within individual circuits that are capable of both mediating the internally ongoing plan as well as representing exogenous sensory events. Here, we investigated how sensory-driven neural activity can be integrated, very often in the same neuron types, into ongoing saccade motor commands. Despite the ballistic nature of saccades, visually induced action potentials in the rhesus macaque superior colliculus (SC), a structure known to drive eye movements, not only occurred intra-saccadically, but they were also associated with highly predictable modifications of ongoing eye movements. Such predictable modifications reflected a simultaneity of movement-related discharge at one SC site and visually induced activity at another. Our results suggest instantaneous readout of the SC during movement generation, irrespective of activity source, and they explain a significant component of kinematic variability of motor outputs.

【 授权许可】

CC BY