Where ketamine and dopamine collide

eLife

David J Marcus¹  Michael R Bruchas² 

[1] Department of Anesthesiology and Pain Medicine and Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, United States;Department of Anesthesiology and Pain Medicine, Center for Neurobiology of Addiction, Pain, and Emotion, and Department of Pharmacology, University of Washington, Seattle, United States;

关键词: dopamine;    aversive learning;    ketamine;    mPFC;    VTA;    antidepressants;    Mouse;   

DOI  :  10.7554/eLife.70148

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Ketamine strengthens connections between two brain regions that are involved in the production and regulation of dopamine, which may explain how the drug can alleviate depression.

【 授权许可】

CC BY