Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans

eLife

Michael Wibral¹  Klaus Lieb²  Patrick Jung²  Arian Mobascher²  Alexandra Sebastian²  Oliver Tüscher²  Pascal Fries³  Edoardo Pinzuti⁴  Michael Schaum⁴ 

[1] Campus Institute Dynamics of Biological Networks, Georg-August University, Göttingen, Germany;Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University, Mainz, Germany;Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany;Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands;Systemic Mechanisms of Resilience, Leibniz Institute for Resilience Research, Mainz, Germany;

关键词: response inhibition;    attention;    pre-supplementary motor area;    stop signal task;    stopping;    Human;   

DOI  :  10.7554/eLife.61679

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Motor inhibitory control implemented as response inhibition is an essential cognitive function required to dynamically adapt to rapidly changing environments. Despite over a decade of research on the neural mechanisms of response inhibition, it remains unclear, how exactly response inhibition is initiated and implemented. Using a multimodal MEG/fMRI approach in 59 subjects, our results reliably reveal that response inhibition is initiated by the right inferior frontal gyrus (rIFG) as a form of attention-independent top-down control that involves the modulation of beta-band activity. Furthermore, stopping performance was predicted by beta-band power, and beta-band connectivity was directed from rIFG to pre-supplementary motor area (pre-SMA), indicating rIFG’s dominance over pre-SMA. Thus, these results strongly support the hypothesis that rIFG initiates stopping, implemented by beta-band oscillations with potential to open up new ways of spatially localized oscillation-based interventions.

【 授权许可】

CC BY