期刊论文详细信息
eLife
Alcohol consumption in the general population is associated with structural changes in multiple organ systems
Wenjia Bai1  Paul M Matthews2  Hideaki Suzuki3  Evangelos Evangelou4  He Gao5  Paul Elliott6  Raha Pazoki7 
[1] Department of Brain Sciences, Imperial College London, London, United Kingdom;Data Science Institute, Imperial College London, London, United Kingdom;Department of Brain Sciences, Imperial College London, London, United Kingdom;UK Dementia Research Institute at Imperial College London, London, United Kingdom;National Institute for Health Research Imperial College Biomedical Research Centre, Imperial College London, London, United Kingdom;Department of Cardiovascular Medicine, Tohoku University Hospital, Sendai, Japan;Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan;Department of Brain Sciences, Imperial College London, London, United Kingdom;Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece;Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom;Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom;UK Dementia Research Institute at Imperial College London, London, United Kingdom;National Institute for Health Research Imperial College Biomedical Research Centre, Imperial College London, London, United Kingdom;British Heart Foundation Centre for Research Excellence, Imperial College London, London, United Kingdom;MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom;Division of Biomedical Sciences, Department of Life Sciences, College of Health, Medicine and Life Sciences, Brunel University London, London, United Kingdom;
关键词: alcohol consumption;    imaging;    brain;    heart;    aorta;    liver;    None;   
DOI  :  10.7554/eLife.65325
来源: eLife Sciences Publications, Ltd
PDF
【 摘 要 】

Background:Excessive alcohol consumption is associated with damage to various organs, but its multi-organ effects have not been characterised across the usual range of alcohol drinking in a large general population sample.Methods:We assessed global effect sizes of alcohol consumption on quantitative magnetic resonance imaging phenotypic measures of the brain, heart, aorta, and liver of UK Biobank participants who reported drinking alcohol.Results:We found a monotonic association of higher alcohol consumption with lower normalised brain volume across the range of alcohol intakes (–1.7 × 10−3 ± 0.76 × 10−3 per doubling of alcohol consumption, p=3.0 × 10−14). Alcohol consumption was also associated directly with measures of left ventricular mass index and left ventricular and atrial volume indices. Liver fat increased by a mean of 0.15% per doubling of alcohol consumption.Conclusions:Our results imply that there is not a ‘safe threshold’ below which there are no toxic effects of alcohol. Current public health guidelines concerning alcohol consumption may need to be revisited.Funding:See acknowledgements.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO202106210530054ZK.pdf 1472KB PDF download
  文献评价指标  
  下载次数:2次 浏览次数:3次