Use of hyaluronan (Gengigel) in the treatment of gingivitis in orthodontic patients: A clinical, biochemical, and microbiological study

Journal of the International Clinical Dental Research Organization

article

Palak D Batavia¹  Kala S Bhushan¹  KL Vandana¹  Rajendra Desai² 

[1] Department of Periodontics, College of Dental Sciences;Department of Oral and Maxillofacial Surgery, College of Dental Sciences

关键词: Gel;    gingival crevicular fluid (GCF);    gingivitis;    hyaluronan;    orthodontic brackets;    L-lactate dehydrogenase (LDH);   

DOI  :  10.4103/2231-0754.176255

来源: Panstwowy Zaklad Wydawnictw Lakarskich

【 摘 要 】

Introduction: To compare the effects of hyaluronan (Gengigel) alone and in combination with scaling using clinical, microbial, and lactate dehydrogenase (LDH) parameters. Materials and Methods: In this, the three treatment groups included were scaling, scaling plus local application of Gengigel, and Gengigel alone. The 0.2% hyaluronic acid (HA) gel was applied topically and intrasulcularly 0.8% hyaluronan was applied. The clinical parameters, and microbial and biochemical analyses of gingival crevicular fluid (GCF) LDH were assessed. Intragroup comparisons were made by Student«SQ»s unpaired t -test and intergroup comparisons were done using one-way analysis of variance followed by post hoc Turkey«SQ»s test. Results: At the end of study period (0-56 day), intergroup comparison demonstrated no significant reduction in plaque index (PI) (0.07 NS), gingival index (GI) (0.99 NS), and LDH (0.70 NS) values. A significant correlation was found between LDH values and bleeding index at all study intervals (0 days, 28 days, and 56 days); gingival index (GI) (0.007 S) was significantly correlated on day 0 and day 56. The microbial reduction was demonstrated. Conclusion: These changes in the clinical, microbial, and biochemical parameters reported with the different treatment modalities clearly support that the use of Gengigel would act as an advantageous adjunct to scaling. Further studies are required to confirm the Gengigel effect using histologic methods.

【 授权许可】

Unknown