Dissociative Tremor Response with Pallidal Deep Brain Stimulation in Parkinson’s Disease

Tremor and Other Hyperkinetic Movements

article

Anson Wang¹  Eric Molho²  Yingmai Yang¹  Julie Pilitsis⁴  Adolfo Ramirez-Zamora¹ 

[1] Department of Neurology, University of Florida;Department of Neurology, Albany Medical Center;Peking Union Medical College Hospital;Department of Neurosurgery, Albany Medical Center;Department of Neuroscience & Experimental Therapeutics, Albany Medical College

关键词: Deep brain stimulation;    GPi;    VIM;    Tremor;    Parkinson’s disease;   

DOI  :  10.5334/tohm.568

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Pallidal and subthalamic targets are commonly used for deep brain stimulation in Parkinson’s disease (PD), with similar efficacy for resting tremor control. However, neuromodulatory effects on kinetic and postural tremor in PD is less clear. Case Report: We present a 67-year-old PD patient with marked dissociative tremor response following pallidal neuromodulation. We observed excellent resting tremor suppression, but postural and kinetic tremors remained severe, requiring additional thalamic VIM stimulation for management. Discussion: Our findings illustrate the phenotypical differences in PD and differential response to diverse tremor characteristics with distinctive stimulation targets. Additional studies are necessary to understand these differences.

【 授权许可】

CC BY