PANDAS: The Need to Use Definitive Diagnostic Criteria

Tremor and Other Hyperkinetic Movements

article

Harvey S. Singer¹ 

[1] Departments of Neurology and Pediatrics, The Johns Hopkins Hospital

关键词: PANDAS;    Tics;    Diagnostic Criteria;   

DOI  :  10.5334/tohm.262

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

The entity pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) was initially proposed in 1998.1 The formal diagnosis required that the affected individual meet five specific criteria: prepubertal onset, obsessive compulsive disorder (OCD) and/or a tic disorder, the dramatic sudden explosive onset of symptoms, a relapsing and remitting course of symptoms that are temporally associated with Group A beta-hemolytic streptococcal (GABHS) infection, and the presence of other neuropsychiatric abnormalities (hyperactivity, emotional lability, anxiety, or piano-playing choreiform movements). Since that original report, the PANDAS hypothesis has remained controversial on the basis of both clinical grounds and failure to confirm a definitive immune process.

【 授权许可】

CC BY