Alien Limb Syndrome Responsive to Amantadine in a Patient with Corticobasal Syndrome

Tremor and Other Hyperkinetic Movements

article

Francisco de Assis Aquino Gondim¹  José Wagner Leonel Tavares Júnior¹  Arlindo A. Morais¹  Paulo Marcelo Gondim Sales¹  Horta Goes Wagner¹ 

[1] Neurology Division, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará

关键词: Alien hand syndrome;    amantadine;    corticobasal syndrome;   

DOI  :  10.5334/tohm.253

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Corticobasal syndrome (CBS) is a complex neurodegenerative disorder associated with parkinsonism and alien limb syndrome. Dressing and ideomotor apraxia were reportedly responsive to amantadine. Case Report: A 79-year-old female was referred for evaluation of right hemiparesis. Neurological examination showed dementia, normal ocular movements, mild facial hypomimia, and bradykinesia with right hemiparesis. Nine years later, she developed alien limb syndrome and was diagnosed with CBS. After failure to respond to several medications, alien limb syndrome markedly improved with amantadine. Discussion: To the best of our knowledge, this is the first report of a consistent response of severe, forced dystonic alien limb syndrome to amantadine in a patient with CBS.

【 授权许可】

CC BY