Prenatal and Perinatal Morbidity in Children with Tic Disorders: A Mainstream School-based Population Study in Central Spain

Tremor and Other Hyperkinetic Movements

article

Esther Cubo¹  Montesclaros Hortigüela²  Sandra Jorge-Roldan¹  Selva Esther Ciciliani²  Patricia Lopez¹  Leticia Velasco¹  Emilio Sastre²  Vanesa Ausin³  Vanesa Delgado³  Sara Saez³  José Trejo Gabriel-Galán¹  Jesús Macarrón¹ 

[1] Neurology Department, Hospital Universitario Burgos;Pediatrics Department;Research Unit, Hospital Universitario Burgos

关键词: Tics;    Tourette syndrome;    tobacco;    cesarean delivery;    cohorts;   

DOI  :  10.5334/tohm.200

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: While current research suggests that genetic factors confer the greatest risk for the development of tic disorders, studies of environmental factors are relatively few, with a lack of consistent risk factors across studies. Our aim is to analyze the association of tic disorders with exposure to prenatal and perinatal morbidity. Methods: This was a nested case–control study design. Cases and controls were selected and identified from a mainstream, school-based sample. The diagnosis of tic disorders was assigned by a movement disorder neurologist using ‘Diagnostic and statistical manual of mental disorders, 4th edition, text revision’ criteria, and neuropsychiatric comorbidities were screened using the Spanish computerized version of the Diagnostic Interview Schedule for Children Predictive Scale. Information regarding the exposure to pre-perinatal risk factors was collected by a retrospective review of the birth certificates. Logistic regression analyses were then performed to test the association of tic disorders with pre-perinatal risk factors. Results: Out of 407 participants, complete pre-perinatal data were available in 153 children (64 with tics and 89 without tics). After adjusting for family history of tics, neonatal respiratory distress syndrome, body mass index, prenatal infection, and coexisting comorbid neuropsychiatric disturbances, tic disorders were associated with prenatal exposure to tobacco (odds ratio [OR]=3.07, 95% confidence interval [CI] 1.24–7.60, p=0.007), and cesarean section (OR=5.78, 95% CI 1.60–20.91, p=0.01). Discussion: This nested case–control study of children with tic disorders demonstrates higher adjusted odds for tics in children with exposure to cesarean delivery and maternal smoking. Longitudinal, population-based samples are required to confirm these results.

【 授权许可】

CC BY