Harmaline-Induced Tremor in Mice: Videotape Documentation and Open Questions About the Model

Tremor and Other Hyperkinetic Movements

article

Melody M. Cheng¹  Guomei Tang¹  Sheng-Han Kuo¹ 

[1] Department of Neurology, College of Physicians and Surgeons, Columbia University

关键词: Essential tremor;    harmaline;    mouse;    cerebellum;    inferior olive;   

DOI  :  10.5334/tohm.139

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Harmaline-induced tremor in rodents has been extensively used as an animal model for essential tremor (ET). However, there is no visual documentation in the published literature. Methods: We injected mice subcutaneously with either 20 mg/kg of harmaline hydrochloride or saline and then videotaped the responses. Results: Action and postural tremor in the mouse began 5 minutes after subcutaneous harmaline injection and peaked at approximately 30 minutes. The tremor involved the head, trunk, tail, and four limbs and lasted for approximately 2 hours. The forelimb tremor was postural or action tremor, similar to that observed in ET. Discussion: This video segment provides the first visual documentation of the phenomenology of harmaline-induced tremor in a mouse. We also raise several unanswered questions regarding the use of harmaline-induced tremor to model ET.

【 授权许可】

CC BY