Familial Cortical Myoclonic Tremor with Epilepsy and Cerebellar Changes: Description of a New Pathology Case and Review of the Literature

Tremor and Other Hyperkinetic Movements

article

Sarvi Sharifi¹  Eleonora Aronica²  Johannes H. T. M. Koelman¹  Marina A. J. Tijssen¹  Anne-Fleur van Rootselaar¹ 

[1] Department of Neurology, Academic Medical Center;Department of (Neuro)Pathology, Academic Medical Center;Stichting Epilepsie Instellingen Nederland;Department of Neurology, University Medical Centre Groningen

关键词: Cortical myoclonus;    tremor;    epilepsy;    cerebellar;    benign;    hereditary;   

DOI  :  10.5334/tohm.119

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: Over 60 Asian and European families with cortical myoclonic tremor and epilepsy have been reported under various names. Cerebellar changes may be part of the syndrome. In this study, we report the neuropathology findings in a new Dutch familial cortical myoclonic tremor with epilepsy case and review the literature on this syndrome. Methods: Neuropathological investigations were performed for a third case of the Dutch pedigree. In addition, we searched the literature for pedigrees meeting the criteria for benign familial myoclonic tremor and epilepsy. Results: Our third Dutch case showed cerebellar Purkinje cell changes and a normal cerebral cortex. The pedigrees described show phenotypical differences, cerebellar symptoms and cerebellar atrophy to a variable degree. Japanese pedigrees with linkage to chromosome 8q have been reported with milder disease features than members of Italian pedigrees with linkage to chromosome 2p. French pedigrees (5p) possibly show even more severe and progressive disease, including cognitive changes and cerebellar features. Discussion: Currently, familial cortical myoclonic tremor is not listed by the International League Against Epilepsy, although it can be differentiated from other epileptic syndromes. Genetic heterogeneity and phenotypical differences between pedigrees exist. Cerebellar changes seem to be part of the syndrome in at least a number of pedigrees.

【 授权许可】

CC BY