Methodological Issues in Clinical Drug Development for Essential Tremor

Tremor and Other Hyperkinetic Movements

article

Michael A. Carranza¹  Madeline R. Snyder¹  Rodger J. Elble²  Angelique E. Boutzoukas¹  Theresa A. Zesiewicz¹ 

[1] Department of Neurology, University of South Florida;Department of Neurology, Southern Illinois University School of Medicine

关键词: Essential tremor;    methodology;    tremor;    etiology;   

DOI  :  10.5334/tohm.116

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Essential tremor (ET) is one of the most common tremor disorders in the world. Despite this, only two medications have received Level A recommendations from the American Academy of Neurology to treat it (primidone and propranolol). Even though these medications provide relief to a large group of ET patients, up to 50% of patients are non-responders. Additional medications to treat ET are needed. This review discusses some of the methodological issues that should be addressed for quality clinical drug development in ET.

【 授权许可】

CC BY