Examining the Motor Phenotype of Patients with Both Essential Tremor and Parkinson’s Disease

Tremor and Other Hyperkinetic Movements

article

Rita M. Simões¹  Anne Constantino²  Eliza Gibadullina²  David Houghton²  Elan D. Louis³  Irene Litvan² 

[1] Hospital Professor Dr. Fernando Fonseca – EPE;Division of Movement Disorders, University of Louisville School of Medicine, Department of Neurology;GH Sergievsky Center, College of Physicians and Surgeons, Columbia University;Department of Neurology, College of Physicians and Surgeons, Columbia University;Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University;Department of Epidemiology, Mailman School of Public Health, Columbia University

关键词: Essential tremor;    Parkinson’s disease;    tremor severity;   

DOI  :  10.5334/tohm.89

学科分类：社会科学、人文和艺术（综合）

来源: Ubiquity Press

【 摘 要 】

Background: The subset of patients with essential tremor (ET) that develops Parkinson’s disease (PD) has not been fully clinically characterized. Methods: Motor features were retrospectively reviewed in 18 ET patients who developed PD (ET→PD), 20 ET and 30 PD patients with similar ages and disease durations. Results: Fewer ET→PD than ET patients had widespread postural and/or action tremor (2/17 [11.8%] vs. 11/17 [64.7%]; p=0.001) and marginally fewer had cerebellar signs (1/15 [6.7%] vs. 6/18 [33.3%], p=0.06). ET→PD patients required fewer ET medications than did their counterparts with ET (p50.001). ET→PD patients and PD patients did not differ in UPDRS, Hoehn and Yahr, or Schwab and England scores (each p≥0.14). Discussion: ET patients who develop PD may have distinct pre-PD motor features compared to their counterparts with ET who do not develop co-existing PD. Prospective studies are needed to evaluate the predictive value of these clinical features for the emergence of PD.

【 授权许可】

CC BY