Is inflammatory pulpal pain a risk factor for amnesia?

The Iranian Journal of Veterinary Science and Technology

article

Raoof, Maryam¹  Raoof, Ramin¹  Abbasnejad, Mehdi³  Esmaeili Mahani, Saeed³  Ramezani, Mohsen⁴  Ebrahim Nejad, Hamed⁵  Amanpour, Sara⁶  Haghani, Jahangir⁷ 

[1] Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences;Department of Endodontics, School of Dentistry, Kerman University of Medical Sciences;Department of Biology, Faculty of Sciences, Shahid Bahonar University;Department of Endodontics, Sari Dental School, Mazandaran University of Medical Sciences;Oral & Maxillofacial Radiology Department, Faculty of Dentistry, Mashhad University of Medical Sciences;Department of Oral Pathology, School of Dentistry, Kerman University of Medical Sciences;Department of Oral & Maxillofacial Radiology, Faculty of Dentistry, Kerman University of Medical Sciences

关键词: odontalgia;    capsaicin;    formalin;    spatial learning and memory;    morris water maze;   

DOI  :  10.22067/veterinary.v6i2.33591

学科分类：医学（综合）

来源: Ferdowsi University of Mashhad

【 摘 要 】

The aim of this study was to investigate the effect of inflammatory pulpal pain on spatial learning and memory in male Wistar rats. Fifty-six adult rats were divided into eight groups as follows (n=7 per group): control, sham-operated group that received normal saline, sham vehicle group that received vehicle of capsaicin, three capsaicin treated groups that received intradental injection of 10, 25 and 100 μg capsaicin, respectively, formalin treated group that received 10 μl formalin 2.5% and ibuprofen treated group that received ibuprofen 20 min before capsaicin (100 μg) injection. After preparing cavities via cutting 2 mm of the distal extremities of the mandibular incisors, the polyethylene crowns were placed on the teeth. Based on the study group, different algesics were administrated under the crowns. After recording the pain scores, spatial learning and memory was assessed using Morris water maze test. Capsaicin 25, 100 μg and formalin 2.5% applications induced significantly more painful stimulation compared with control groups (p< 0.001). Capsaicin 25, 100 μg and also formalin-treated groups significantly showed increased escape latency and traveled distance (p<0.05). Oral administration of ibuprofen, 20 min before capsaicin injection, caused significant decrease in pain scores, escape latency and traveled distance. Our data suggest that capsaicin- and formalin-induced pulpal pain can impair spatial learning and memory of male rats in Morris water maze task.

【 授权许可】

CC BY