Tualang Honey Improves Memory and Prevents Hippocampal Changes in Prenatally Stressed Rats

Turkish Journal of Pharmaceutical Sciences

article

Che Badariah ABD AZIZ¹  Hidani HASIM¹  Rahimah ZAKARIA¹  Asma Hayati AHMAD¹ 

[1] Department of Physiology, Universiti Sains Malaysia

关键词: Prenatal stress;    hippocampus;    Tualang honey;    malondialdehyde;    NMDA receptor;   

DOI  :  10.4274/tjps.galenos.2019.21548

来源: Galenos Yayinevi

【 摘 要 】

Objectives: This study investigated whether the alterations in memory and hippocampus morphology and levels of malondialdehyde (MDA) and N-methyl-D-aspartate (NMDA) receptor in the hippocampus of adult rats after prenatal stress could be prevented by administration of Tualang honey (TH). Materials and Methods: Twenty-four pregnant rats were randomly grouped into a control group (C), a stress group (S), and a stress group treated with TH. Eight male pups from each group were randomly chosen and they were sacrificed at eight or ten weeks of age following the novel object recognition test. Their brains were removed and histological changes and levels of MDA and NMDA receptors in the hippocampus were determined. Results: The offspring from TH group showed significantly increased preference index (p<0.05) with higher neuronal number compared to S group. A significantly lower level of MDA and NMDA receptors were shown in TH group (P<0.01; P<0.05 respectively) compared to S group. The parameters investigated were not significantly different between C and TH groups. Conclusion: The study has shown that memory alteration, changes in hippocampus histology, MDA and NMDA receptor levels could be prevented by TH administration during prenatal stress. The results suggest the beneficial effects of Tualang honey in prenatally stressed rat offspring.

【 授权许可】

Unknown