Tualang Honey Ameliorates Hypoxia-induced Memory Deficits by Reducing Neuronal Damage in the Hippocampus of Adult Male Sprague Dawley Rats

Turkish Journal of Pharmaceutical Sciences

article

Entesar Yaseen Abdo QAID¹  Rahimah ZAKARIA¹  Nurul Aiman MOHD YUSOF²  Shaida Fariza SULAIMAN³  Nazlahshaniza SHAFIN¹  Zahiruddin OTHMAN⁴  Asma Hayati AHMAD¹  Che Badariah ABD AZIZ¹  Sangu MUTHURAJU⁵ 

[1] Universiti Sains Malaysia, School of Medical Sciences, Department of Physiology;Universiti Sains Malaysia, School of Medical Sciences, Department of Anatomy;Universiti Sains Malaysia, School of Biological Sciences;Universiti Sains Malaysia, School of Medical Sciences, Department of Psychiatry;Universiti Sains Malaysia, School of Medical Sciences, Department of Neuroscience

关键词: Hypoxia;    Tualang honey;    sucrose;    memory performance;    novel object recognition task;    T-maze;   

DOI  :  10.4274/tjps.galenos.2019.32704

来源: Galenos Yayinevi

【 摘 要 】

Objectives: A growing body of evidence indicates that hypoxia exposure causes learning and memory deficits. An effective natural therapeutic approach has, however, not been explored widely. Our previous studies found that Tualang honey administration protected learning and memory functions in ovariectomized rats. Therefore, the present study investigated its efficacy in ameliorating hypoxia-induced memory deficits in adult male Sprague Dawley rats. Materials and Methods: The rats were divided into four groups: i) Normoxia treated with sucrose (n=12), ii) Normoxia treated with Tualang honey (n=12), iii) Hypoxia treated with sucrose (n=12), and iv) Hypoxia treated with Tualang honey (n=12). Tualang honey (0.2 g/kg/BW) and sucrose (1 mL of 7.9%) supplementations were administered orally to the rats daily for 14 days. Then the hypoxia groups were exposed to hypoxia (~11%) for 7 days, while the normoxia groups were kept in normal conditions. Following exposure to hypoxia, the rats’ memories were analyzed using a novel object recognition task and T-maze test. Results: The data revealed that rats exposed to hypoxia showed significant impairment in short-term memory (STM), spatial memory (p<0.01), and long-term memory (LTM) when compared to the normoxia group. Hypoxia rats treated with Tualang honey showed significant improvement in STM, LTM, and spatial memory (p<0.05) compared with those treated with sucrose (p<0.05). Tualang honey also reduced neuronal damage in the hippocampus of adult male Sprague Dawley rats exposed to hypoxia. Conclusion: It is suggested that Tualang honey pretreatment has protective effects against hypoxia-induced memory deficits, possibly through its antioxidant contents.

【 授权许可】

Unknown