Design and In Vitro Characterization of Orally Disintegrating Modified Release Tablets of Naproxen Sodium

Turkish Journal of Pharmaceutical Sciences

article

Amjad HUSSAIN¹  Maham MISBAH¹  Nasir ABBAS¹  Muhammad IRFAN²  Muhammad Sohail ARSHAD³  Rahat SHAMIM¹  Nadeem Irfan BUKHARI¹  Faisal MAHMOOD¹ 

[1] University College of Pharmacy, University of the Punjab;Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, GC University Faisalabad;Faculty of Pharmacy, Bahauddin Zakariya University

关键词: Orally disintegrating tablets;    modified release tablets;    naproxen sodium;    Soluplus®;   

DOI  :  10.4274/tjps.galenos.2019.24445

来源: Galenos Yayinevi

【 摘 要 】

Objectives: The aim of this study was to prepare orally disintegrating, slow release tablets of naproxen sodium for prompt onset and sustained action required in many types of acute pain. Materials and Methods: Tablet formulations containing varying concentrations of croscarmellose sodium (a superdisintegrant) and Soluplus® (as release modifier) were prepared by wet granulation method using a single punch tablet machine. The prepared granules were evaluated for their bulk properties and the tablets were evaluated for hardness, disintegration time, and drug release profiles. Results: The results showed that the granules so prepared have good flow and compressional properties. A disintegration time of tablets <30 s was achieved by selecting an optimum concentration of croscarmellose sodium. The drug release from the tablets was sustained for 2 h by incorporating a suitable amount of Soluplus®. Conclusion: This study examined the use of Soluplus® (a novel solubilizer) for the first time as a release modifier of API from tablets.

【 授权许可】

Unknown