Evaluation of the Antidiabetic Activity of Alchemilla persica Rothm. in Mice with Diabetes Induced by Alloxan

Turkish Journal of Pharmaceutical Sciences

article

Serkan ÖZBİLGİN¹  Hanefi ÖZBEK²  Neriman İpek KIRMIZI³  Burçin ERGENE ÖZ¹  Ekin KURTUL¹  Bade Cevriye ÖZRENK³  Gülçin SALTAN İŞCAN¹  Özlem BAHADIR ACIKARA¹ 

[1] Ankara University, Faculty of Pharmacy, Department of Pharmacognosy;İstanbul Medipol University, Faculty of Medicine, Department of Pharmacology;stanbul Medipol University, Faculty of Medicine, Department of Vocational School of Health Services

关键词: Alchemilla persica;    alloxan;    antidiabetic activity;    diabetes;    hypoglycemic activity;   

DOI  :  10.4274/tjps.galenos.2018.65487

来源: Galenos Yayinevi

【 摘 要 】

Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well as in Caucasia, northern and northeastern Iran, and northern Iraq. Materials and Methods: Methanolic-water extracts of the aerial parts and roots of A. persica were evaluated for their hypoglycemic activities in mice with alloxan-induced diabetes in order to verify its usage in folk medicine. Results: None of the tested extracts exhibited a significant lowering effect on blood glucose levels. However, the aerial parts notably increased blood glucose levels at doses of 100 mg/kg and 200 mg/kg. Conclusion: A. persica usage as an antidiabetic is not confirmed in the present study.

【 授权许可】

Unknown