Electroanalytical Determination of the Antiinflammatory Drug Tenoxicam in Pharmaceutical Dosage Forms

Turkish Journal of Pharmaceutical Sciences

article

Fatma AĞIN¹  Sena ATAL¹ 

[1] Karadeniz Technical University, Faculty of Pharmacy, Department of Analytical Chemistry

关键词: Glassy carbon electrode;    multiwalled carbon nanotubes;    tenoxicam;    voltammetry;   

DOI  :  10.4274/tjps.galenos.2018.60783

来源: Galenos Yayinevi

【 摘 要 】

Objectives: The electro-oxidation behavior of the non-steroidal anti-inflammatory drug tenoxicam (TX) was studied on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) by cyclic voltammetry, differential pulse voltammetry (DPV), and square wave voltammetry (SWV). Materials and Methods: The GCE was modified with MWCNT for sensitive determination of TX by voltammetric methods. Results: The current peaks for TX occurred at around 0.520 V for DPV and 0.570 V for SWV when the potential was scanned in the positive direction. The oxidation process of TX showed irreversible and diffusion-controlled behavior. The linear responses were obtained in the range from 2×10-7 to 1×10-5 M with the limit of detection (LOD) 1.43×10-9 for DPV and from 8×10-9 to 8×10-6 with the LOD 9.97×10-10 for SWV in 1 M acetate buffer solution at pH 5.5. Conclusion: Fully validated DPV and SWV were successfully applied for the determination of TX from pharmaceutical dosage form and yielded satisfying results.

【 授权许可】

Unknown