Synthesis, Characterization, and Antibacterial Evaluation of New Vanillic Acid Derivatives

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

Mostafa F. Tawfeeq¹  Ahlam J Qassir² 

[1] Department of Pharmacy, College of Pharmacy, University of Tikrit;Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad

关键词: Hydrazide;    Schiff Base;    Oxadiazole;    Antibacterial.;   

DOI  :  10.31351/vol29iss2pp129-138

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

Hydrazide Schiff bases (hydrazones) and 2,5-disubstituted-1,3,4-oxadiazole derivatives exhibit diverse biological activities that include antibacterial, antifungal, antitubercular, antiviral, anticancer, anti-inflammatory, and analgesia; so that new derivatives, compounds (5-8) of vanillic acid based on 1,3,4-oxadiazole as scaffold unit were synthesized through multi-steps, and characterized by thin layer chromatography and spectroscopically by Fourier-transform Infrared (FTIR) and Proton nuclear magnetic resonance (1HNMR). Compounds (5-8) were evaluated for their antibacterial activity by the disk diffusion method. Compounds (5-8) were showed moderate and comparable to the activities of amoxicillin and isoniazid against Escherichia coli (E. coli), but less than that of cefixime and nitrofurantoin which their activities were high. Compound (6) and (7) had shown moderate and comparable to the activities of amoxicillin and cefixime against Klebsiella pneumoniae (K. pneumoniae), but less than that of nitrofurantoin which its activity was high. Compound (6) and (7) had shown moderate and comparable to the activity of amoxicillin against Staphylococcus aureus (S. aureus), while the activities of cefixime and nitrofurantoin were high. Compound (6) was moderately active against Bacillus subtilis (B. subtilis), while the activities of amoxicillin, cefixime, and nitrofurantoin were high.

【 授权许可】

CC BY