Ex-vivo Ex-Vivo Absorption Study of a Novel Dabigatran Etexilate Loaded Nanostructured Lipid Carrier Using Non-Everted Intestinal Sac Model

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

haithem N Abed¹  Ahmed A. Hussein² 

[1] Ministry of Health and Environment,Directorate of Diyala;Department of Pharmaceutics, University of Baghdad

关键词: Dabigatran Etexilate;    NLCs;    Ex-vivo intestinal permeation;    thrombin inhibitor;    Cremophor-EL.;   

DOI  :  10.31351/vol28iss2pp37-45

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

The purpose of the study was to develop Dabigatran Etexilate loaded nanostructured lipid carriers (DENLCs) using Glyceryl monostearate and Oleic acid as lipid matrix, and to estimate the potential of the developed delivery system to improve oral absorption of low bioavailability drug, different Oleic acid ratios effect on particle size, zeta potential, entrapment efficiency and loading capacity were studied, the optimized DE-NLCs shows a particle size within the nanorange, the zeta potential (ZP) was 33.81±0.73mV with drug entrapment efficiency (EE%) of 92.42±2.31% and a loading capacity (DL%) of 7.69±0.17%. about 58.5% of drug was released in 8hr in a controlled manner, the ex-vivo intestinal permeation study using the non-everted sac model shows four folds increment in the permeation of DE-NLCs compared to dabigatran etexilate suspension (DE-S).

【 授权许可】

CC BY