Dissolution Enhancement of Raltegravir by Hot Melt Extrusion Technique

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

Ahmed S. Abdul Jabbar¹ 

[1] Department of Pharmaceutics, College of Pharmacy, University of Basrah

关键词: Hot melt extrusion;    Raltegravir;    Plasdone S630.;   

DOI  :  10.31351/vol27iss1pp20-29A

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

The objective of the study to develop an amorphous solid dispersion for poorly soluble raltegravir by hot melt extrusion (HME) technique. A novel solubility improving agent plasdone s630 was utilized. The HME raltegravir was formulated into tablet by direct compression method. The prepared tablets were assessed for all pre and post-compression parameters. The drug- excipients interaction was examined by FTIR and DSC. All formulas displayed complying with pharmacopoeial measures. The study reveals that formula prepared by utilizing drug and plasdone S630 at 1:1.5 proportion and span 20 at concentration about 30mg (trail-6) has given highest dissolution rate than contrasted with various formulas of raltegravir.

【 授权许可】

CC BY