Synthesis of new Conjugates of some NSAIDs with Sulfonamide as Possible Mutual Prodrugs using Tyrosine Spacer for Colon Targeted Drug Delivery

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

Shayma L. Abdulhadi¹  Ahlam J. Qasir¹  Nadeem A. Abdul Razzak¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad

关键词: Mutual prodrug;    Ester linkage;    Azo bond;    Colon targeting;   

DOI  :  10.31351/vol22iss2pp22-29

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

The purpose of this research work is to synthesize conjugates of some NSAIDs with sulfamethoxazole as possible mutual prodrugs to overcome the local gastric irritation of NSAID with free carboxyl group by formation of ester linkage that supposed to remain intact in stomach and may hydrolyze in intestine chemically or enzymatically; in addition to that attempting to target the synthesized derivative to the colon by formation of azo group that undergo reduction only by colonic bacterial azo reductaze enzyme to liberate the parent compound to act locally (treatment of inflammation and infections in colon).

【 授权许可】

CC BY