Design and Synthesis of Some Nitrate Derivatives of Mefenamic Acid with Expected Nitric Oxide Release

Iraqi Journal of Pharmaceutical Sciences

ARTICLE

Ahmed A. Sadon¹  Ahlam J. Qasir¹ 

[1] Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad

关键词: Non-Steroidal anti-inflammatory drugs (NSAIDs);    Glycine;    Mefenamic acid;    Organic nitrates;    Nitric oxide (NO).;   

DOI  :  10.31351/vol21iss2pp24-30

学科分类：计算机网络和通讯

来源: College of Pharmacy University of Baghdad

【 摘 要 】

This study include design and synthesis of 2 derivatives of compounds consisting of mefenamic acid, glycine and organic nitrates (2-nitrooxy ethanol or 1,3-dinitrooxy-2-propanol). Nitric oxide NO has been reported to support many of the same mucosal protection mechanisms as prostaglandins and is sufficient for acute gastroprotection and ulcer healing. So we suppose these 2 compounds would reduce non-steroidal antiinflammatory drugs NSAIDs gastrointestinal side effect. Key words: Non-Steroidal anti-inflammatory drugs (NSAIDs), Glycine, Mefenamic acid, Organic nitrates, Nitric oxide (NO).

【 授权许可】

CC BY