The Role of Anxiety and Cortisol in Outcomes of Patients With Covid-19

Basic and Clinical Neuroscience

ARTICLE

Ramezani, Mahtab¹  Simani, Leila¹  Karimialavijeh, Ehsan²  Rezaei, Omidvar¹  Hajiesmaeili, Mohammadreza³  Pakdaman, Hossein⁴ 

[1] Skull-Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences;Department of Emergency Medicine, Sina Hospital, Tehran University of Medical Sciences;Anesthesiology Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences;Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences

关键词: COVID-19;    Stress;    Cortisol;    Anxiety;   

DOI  :  10.32598/bcn.11.covid19.1168.2

来源: Iran University of Medical Sciences

【 摘 要 】

Introduction: The outbreak due to Coronavirus Disease 2019 (COVID-19) is n global public health emergency and challenges psychological resilience. The central nervous system, endocrine system, and immune system are complex interacting systems. Cortisol has been implicated as the cause of a wide range of mental and physical health disorders; however, the impact of cortisol on outcomes in patients with COVID-19 is not clear. Methods:The current study enrolled patients with COVID-19 (onset of disease within 7 days of the first symptom) to evaluate the serum concentration of cortisol and levels of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) to investigate a possible relationship between cortisol, depression, and anxiety levels and outcomes of patients with COVID-19. Results: A total of 30 patients with COVID-19 were studied. The levels of cortisol and HADS score in patients who died of Covid-19 were significantly higher in comparison with surviving patients (P<0.017 and P<0.001 respectively). We also found that the HADS score was positively correlated with serum cortisol levels (r= 0.842, P=0.004). Conclusion: Our findings showed that stress and anxiety are associated with patients’ outcomes. Psychological interventions can improve the mental health of vulnerable groups during the COVID-19 epidemic.

【 授权许可】

Unknown