期刊论文详细信息
Basic and Clinical Neuroscience
Prediction of Brain Connectivity Map in Resting-State fMRI Data Using Shrinkage Estimator
ARTICLE
Nazari, Atiye1  Alavimajd, Hamid1  Shakeri, Nezhat1  Bakhshandeh, Mohsen2  Faghihzadeh, Elham1  Marzbani, Hengameh3 
[1] Department of Biostatistics, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences;Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences;Department of Biomedical Engineering and Medical Physics, School of Medicine, Tehran University of Medical Sciences
关键词: Resting-State fMRI;    Functional connectivity;    Shrinkage estimator;    Mean Squared Error;    Seed-based correlation analysis;   
DOI  :  10.32598/bcn.9.10.140
来源: Iran University of Medical Sciences
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【 摘 要 】

Introduction: In recent years, brain functional connectivity studies are extended using the advanced statistical methods. Functional connectivity is identified by synchronous activation in a spatially distinct region of the brain in resting-state functional Magnetic Resonance Imaging (MRI) data. For this purpose there are several methods such as seed-based correlation analysis based on temporal correlation between different Regions of Interests (ROIs) or between brain’s voxels of prior seed. Methods: In the current study, test-retest Resting State functional MRI (rs-fMRI) data of 21 healthy subjects were analyzed to predict second replication connectivity map using first replication data. A potential estimator is “raw estimator” that uses the first replication data from each subject to predict the second replication connectivity map of the same subject. The second estimator, “mean estimator” uses the average of all sample subjects' connectivity to estimate the correlation map. Shrinkage estimator is made by shrinking raw estimator towards the average connectivity map of all subjects' first replicate. Prediction performance of the second replication correlation map is evaluated by Mean Squared Error (MSE) criteria. Results: By the employment of seed-based correlation analysis and choosing precentral gyrus as the ROI over 21 subjects in the study, on average MSE for raw, mean and shrinkage estimator were 0.2169, 0.1118, and 0.1103, respectively. Also, percent reduction of MSE for shrinkage and mean estimator in comparison with raw estimator is 49.14 and 48.45, respectively. Conclusion: Shrinkage approach has the positive effect on the prediction of functional connectivity. When data has a large between session variability, prediction of connectivity map can be improved by shrinking towards population mean.

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